Tag: naldemedine
Managing Opioid Constipation: How Peripherally Acting Mu Antagonists Work
PAMORAs like methylnaltrexone, naloxegol, and naldemedine treat opioid constipation without reducing pain relief. They work in the gut, not the brain, and can restore bowel function in over 40% of patients. Learn how they compare, who they help, and why cost remains a barrier.